UCR

Neuroscience Graduate Program



Fundamentals of Neuroscience: NRSC 200A


NRSC 200A
Fundamentals of Neuroscience: Molecular and cellular mechanisms

Lecture: INTS 1130, TR, 11:10 am - 12:30 pm, 3 cr.
Prof. Scott Currie, Office: Spieth 2380, Tel: 827-2411
Go to Scott Currie's Neuroscience Faculty page
Office hours: MW 1:00 - 2:00 pm

TEXTBOOKS: Nicholls et al., From Neuron to Brain, 5th Ed., Sinauer Associates, 2012.

Text cover image

For to me, life consists simply in this, in the fluctuations between two poles, in the hither and thither between the two foundation pillars of the world.

 Herman Hesse [A Guest at the Spa. (1924),  In: Autobiographical Writings]

Depolarization-activated bursting in turtle spinal interneuron

Whole-cell patch recording from bursting turtle spinal dorsal horn interneuron

GRADING

  • Take Home Exam 1  (25%)
  • Take Home Exam 2  (25%)
  • Term Paper  (25%)
  • Oral presentation of Term Paper topic  (25%)
DATES
TOPIC
READING
Sept 24
  • Course organization, Neurons and electrical signaling

Nicholls: 3-22

Sept 29, Oct 1
    • Ion channelsion channels

Web Links:
- Erwin Neher & Bert Sakmann
- Roderick MacKinnon - Nobel lecture 2003

Nicholls: 63-97

Oct 6
  • Resting Membrane Potential

Web Links:

The squid giant axon preparation 
- Membrane Potential Tutorial (William J. Heitler, St. Andrews Univ.)
Julius Bernstein: pioneer neurobiologist and biophysicist

Nicholls: 99-111, 143-147

Oct 8, 13
  • Action potentials
Cole and Curtis (1939) - increased conductance in squid axon during action potential


Web Links:
  - Alan Hodgkin & Andrew Huxley

  - Alan Hodgkin's obituary 1998

  - Andrew Huxley - 2007 interview
  - Reconstruction of the action potential

  - The Brunsviga 20 mechanical calculator
  - John Moore's first-person account of the pioneers: Cole, Hodgkin, & Huxley

  - Tetrodotoxin - pufferfish venom

 

Nicholls: 113-128

Oct 15
    • Neurons as conductors of electricity


Take Home Exam 1 available on iLearn.  Turn in by Oct 20.

Nicholls: 129-141

Oct 20, 22
    • Neuroglia

Nicholls: 159-180

Oct 27, 29
    • Synaptic transmission I:

  - electrical and "direct" (ionotropic) chemical transmission



Nicholls: 185-210

 

Nov 3
    • Synaptic transmission II:

- "indirect" (metabotropic) chemical transmission & neuromodulation

Web Links:
- Alfred Gilman & Martin Rodbell

Nicholls: 213-240

Nov 5
    • Synaptic transmission III:

    - mechanisms of transmitter release

Web Links:
    - Presynaptic proteins, synaptic vesicle docking & membrane fusion

    - Bernard Katz (Nobel Prize site)

    - Memories of Bernard Katz (2003 talk by Paul Fatt)

Nicholls: 243-271

Nov 10

Nicholls: 317-333

Nov 12, 17
    • Sensory receptors and transduction I:hair cell

    - overview & mechanoreceptors

Web Links:
  - Georg von Békésy

  - Brain Briefings: Deafness Genes

 

Term Paper due.

Nicholls: 385-397, 433-436, 453-464

19
    • Sensory receptors and transduction II:

    - chemoreceptors, thermoreceptors & nociceptorstshirt with tongue sticking out

Web Links:
   - The Chemoreception web

   - Our Chemical Senses: Olfaction

   - Our Chemical Senses: Taste

    - Brain Briefings: Taste Intensity

Nicholls: 397-404

Nov 24
    • Sensory receptors and transduction III:green eye

    - photoreceptors & retinal signaling

Web Links:
 - Ragnar Granit, H.K. Hartline & George Wald

 - Brain Briefings: Light Detection & Melanopsin

 - Brain Briefings: Eye Repair

 

Take Home Exam 2 available on iLearn Nov 24.  Turn in by Dec 1.

Nicholls: 407-430

Nov 26
    • NO CLASS - ACADEMIC HOLIDAY (THANKSGIVING)

 

Dec 1, 3
  • Oral presentations.
 
Dec 7-10

[FINALS WEEK]

  • Oral presentations. (Dates and times to be arranged.)
 

More Information

General Campus Information

University of California, Riverside
900 University Ave.
Riverside, CA 92521
Tel: (951) 827-1012

Career OpportunitiesUCR Libraries
Campus StatusDirections to UCR

Program Information

Cell Biology and Neuroscience
1001 Batchelor Hall

Perla Fabelo, Graduate Student Affairs Officer
Ph.D. Program in Neuroscience
Tel: (951) 827-4716
Toll Free (800) 735-0717
E-mail: neuro@mail.ucr.edu

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